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NANOFOLD - Peptide foldamer-based nanostructures as potential carriers of antiparasitic drugs
Title: NANOFOLD - Peptide foldamer-based nanostructures as potential carriers of antiparasitic drugs
Funding: Polish National Agency for Academic Exchange (NAWA, Poland), Bilateral exchange of scientists between the Republic of Poland and the Portuguese Republic
Project number: BPN/BPT/2021/1/00012/U/00001
Cost: PLN 22 250.00
Duration: 01.01.2022 – 31.12.2023
Abstract: Antiparasitic drugs in use or in the clinical pipeline pose many challenges, as toxicity or low bioavailability. This can be solved by encapsulation, as in liposomes or AmBisome®, a liposome-based Amphotericin B formulation used in leishmaniosis. However, high production and delivery costs due to liposomal instability are a major hurdle for diseases endemic to [sub-]tropical low-to-middle income countries. The Portuguese (PT) and Polish (PL) teams wish to jointly tackle this issue by addressing alternate drug carriers. The PT team lead by prof. Paula Gomes (Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto) has long track record in antiparasitic drugs, and the PL team lead by dr. Monika Szefczyk is expert in peptide foldamers as nanocarriers. Antiparasitics produced in PT will be encapsulated in nanocarriers developed in PL, and formulations thereof will be evaluated for antiparasitic action and drug release in vitro. Identification of at least two promising nanocarriers for antiparasitic drugs is expected.
Publications:
- Monika Szefczyk, Juan Lizandra Pérez, Anna Szczepańska, Paulina Fortuna, Alternative Carriers in Drug Delivery Systems – Peptide Foldamers. Proceedings of the 8th World Congress on Recent Advances in Nanotechnology (RAN'23), Lisbon, Portugal – March 23 – 25, 2023, Paper No. ICNNFC 109, DOI: 10.11159/icnnfc23.109.