Born: June 2nd, 1976, Wrocław, Poland

Room: 322A, building A2

Phone: +48 71 320 3344

e-mail: lukasz.berlicki@pwr.edu.pl

Hobby: travel photography, LEGO bricks

ORCID: 0000-0003-0318-4944

Google Scholar: 9RfrYGsAAAAJ

Scopus ID: 6507332551

Web of Science ID: AAB-2140-2019

Education

2020 – Professor, Faculty of Chemistry, Wrocław University of Science and Technology, Poland

2012 – Habilitation in Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Poland

2004 – PhD in Chemistry, supervisor: prof. Paweł Kafarski, Faculty of Chemistry, Wrocław University of Technology, Poland

2000 – MSc in Computer Science, Faculty of Electronics, Wrocław University of Technology, Wrocław, Poland

2000 – MSc in Chemistry, Faculty of Chemistry, University of Wrocław, Poland

Scholarships

• 2009-2010, Faculty of Chemistry, University of Regensburg, Marie Curie Fellowship of European Commision, with prof. Oliver Reiser;
• 1999, Faculty of Chemistry, University of Bari, Erasmus Fellowship, with prof. M. Aresta.

Research

• design, synthesis, biological and catalytic activity of peptide foldamers;
• design and synthesis of enzyme inhibitors and protein-protein interaction inhibitors

Cooperation

• prof. T. Holak, Jagiellonian University
• prof. W. Rypniewski, Institute of Bioorganic Chemistry PAS, Poznań;
• dr. S. Vassiliou, University of Athens;
• prof. T. Martinek, University of Szeged;
• prof. J. Grembecka, University of Michigan;

Recent Publications (All Publications)

1. Ożga, K.; Rudzińska-Szostak, E.; Berlicki, Ł. Optimization of peptide foldamer-based artificial retro-aldolase, Cat. Sci. Tech. 2024, accepted. View at Publisher
2. Ciesiołkiewicz, A.; Lizandra Perez, J.; Skalniak, L.; Noceń, P.; Berlicki, Ł. Miniprotein engineering for inhibition of PD‐1/PD‐L1 interaction, Protein Sci. 2024, 33, e5106. View at Publisher
3. Kovalenko, V.; Rudzińska-Szostak, E.; Ślepokura, K.; Berlicki, Ł. Scalable Synthesis of All Stereoisomers of 2-Aminocyclopentanecarboxylic Acid─A Toolbox for Peptide Foldamer Chemistry. J Org Chem 2024, 89 (7), 4760–4767. View at Publisher.
4. Marković, V.; Szczepańska, A.; Berlicki, Ł. Antiviral Protein–Protein Interaction Inhibitors. J Med Chem 2024, 67 (5), 3205–3231. View at Publisher.
5. Grelich-Mucha, M.; Bachelart, T.; Torbeev, V.; Ożga, K.; Berlicki, Ł.; Olesiak-Bańska, J. Biomaterials Sci 2024, 12 (6), 1590-1602. View at Publisher.
6. Rodriguez, I.; Kocik-Krol, J.; Skalniak, L.; Musielak, B.; Wisniewska, A.; Ciesiołkiewicz, A.; Berlicki, Ł.; Plewka, J.; Grudnik, P.; Stec, M.; Siedlar, M.; Holak, T. A.; Magiera-Mularz, K. Structural and Biological Characterization of PAC65, a Macrocyclic Peptide That Blocks PD-L1 with Equivalent Potency to the FDA-Approved Antibodies. Mol Cancer 2023, 22 (1), 150. View at Publisher.
7. Tabor, W.; Katsogiannou, A.; Karta, D.; Andrianopoulou, E.; Berlicki, Ł.; Vassiliou, S.; Grabowiecka, A. Exploration of Thiourea-Based Scaffolds for the Construction of Bacterial Ureases Inhibitors. ACS Omega 2023, 8 (31), 28783–28796. View at Publisher.
8. Maślanka, M.; Tabor, W.; Krzyżek, P.; Grabowiecka, A.; Berlicki, Ł.; Mucha, A. Inhibitory Activity of Catecholic Phosphonic and Phosphinic Acids against Helicobacter Pylori Ureolysis. Eur J Med Chem 2023, 257, 115528. View at Publisher.
9. Szefczyk, M.; Szulc, N.; Gąsior-Głogowska, M.; Bystranowska, D.; Żak, A.; Sikora, A.; Polańska, O.; Ożyhar, A.; Berlicki, Ł. The Application of the Hierarchical Approach for the Construction of Foldameric Peptide Self-Assembled Nanostructures. Soft Matter 2023, 19 (21), 3828–3840. View at Publisher.
10. Marković, V.; Shaik, J. B.; Ożga, K.; Ciesiołkiewicz, A.; Lizandra Perez, J.; Rudzińska-Szostak, E.; Berlicki, Ł. Peptide Foldamer-Based Inhibitors of the SARS-CoV-2 S Protein–Human ACE2 Interaction. J Enzyme Inhib Med Chem 2023, 38 (1). View at Publisher.
11. Macegoniuk, K.; Tabor, W.; Mazzei, L.; Cianci, M.; Giurg, M.; Olech, K.; Burda-Grabowska, M.; Kaleta, R.; Grabowiecka, A.; Mucha, A.; Ciurli, S.; Berlicki, Ł. Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action. J Med Chem 2023, 66 (3), 2054–2063. View at Publisher.
12. Loharch, S.; Berlicki, Ł. Rational Development of Bacterial Ureases Inhibitors. The Chemical Record 2022, 22 (8). View at Publisher.
13. Berlicki, Ł. Tailoring Peptides and Peptidomimetics for Targeting Protein–Protein Interactions. In Peptide and Peptidomimetic Therapeutics; Elsevier, 2022; pp 57–71. View at Publisher.
14. Vassiliou, S.; Pagoni, A.; Węglarz-Tomczak, E.; Talma, M.; Tabor, W.; Grabowiecka, A.; Berlicki, Ł.; Mucha, A. Phosphinic Acid-Based Enzyme Inhibitors. Phosphorus Sulfur Silicon Relat Elem 2022, 197 (5–6), 451–456. View at Publisher.
15. Szefczyk, M.; Ożga, K.; Drewniak-Świtalska, M.; Rudzińska-Szostak, E.; Hołubowicz, R.; Ożyhar, A.; Berlicki, Ł. Controlling the Conformational Stability of Coiled-Coil Peptides with a Single Stereogenic Center of a Peripheral β-Amino Acid Residue. RSC Adv 2022, 12 (8), 4640–4647. View at Publisher.
16. Ożga, K.; Berlicki, Ł. Design and Engineering of Miniproteins. ACS Bio & Med Chem Au 2022, 2 (4), 316–327. View at Publisher.
17. Ciesiołkiewicz, A.; Lizandra Perez, J.; Berlicki, Ł. Miniproteins in Medicinal Chemistry. Bioorg Med Chem Lett 2022, 71, 128806. View at Publisher.
18. Stanojlovic, V.; Müller, A.; Moazzam, A.; Hinterholzer, A.; Ożga, K.; Berlicki, Ł.; Schubert, M.; Cabrele, C. A Conformationally Stable Acyclic Β‐Hairpin Scaffold Tolerating the Incorporation of Poorly Β‐Sheet‐Prone Amino Acids. ChemBioChem 2022, 23 (4). View at Publisher.
19. Pagoni, A.; Grabowiecka, A.; Tabor, W.; Mucha, A.; Vassiliou, S.; Berlicki, Ł. Covalent Inhibition of Bacterial Urease by Bifunctional Catechol-Based Phosphonates and Phosphinates. J Med Chem 2021, 64 (1), 404–416. https://doi.org/10.1021/acs.jmedchem.0c01143 View at Publisher.
20. Ożga, K.; Drewniak‐Świtalska, M.; Rudzińska‐Szostak, E.; Berlicki, Ł. Towards Foldameric Miniproteins: A Helix‐Turn‐Helix Motif. Chempluschem 2021, 86 (4), 646–649. View at Publisher.
21. Szefczyk, M.; Szulc, N.; Gąsior-Głogowska, M.; Modrak-Wójcik, A.; Bzowska, A.; Majstrzyk, W.; Taube, M.; Kozak, M.; Gotszalk, T.; Rudzińska-Szostak, E.; Berlicki, Ł. Hierarchical Approach for the Rational Construction of Helix-Containing Nanofibrils Using α,β-Peptides. Nanoscale 2021, 13 (7), 4000–4015. View at Publisher.
22. Drewniak-Świtalska, M.; Barycza, B.; Rudzińska-Szostak, E.; Morawiak, P.; Berlicki, Ł. Constrained Beta-Amino Acid-Containing Miniproteins. Org Biomol Chem 2021, 19 (19), 4272–4278. View at Publisher.
23. Bejger, M.; Fortuna, P.; Drewniak-Świtalska, M.; Plewka, J.; Rypniewski, W.; Berlicki, Ł. A Computationally Designed β-Amino Acid-Containing Miniprotein. Chemical Communications 2021, 57 (49), 6015–6018. View at Publisher.
24. Grelich-Mucha, M.; Garcia, A. M.; Torbeev, V.; Ożga, K.; Berlicki, Ł.; Olesiak-Bańska, J. Autofluorescence of Amyloids Determined by Enantiomeric Composition of Peptides. J Phys Chem B 2021, 125 (21), 5502–5510. View at Publisher.