Room: 302, building A2

Phone: +48 71 320 37 04

e-mail: natalia.miodowska@pwr.edu.pl

Hobby: forensics and criminology, literature and Polish grammar, culinary

ORCID: 0000-0002-6753-2971

Web of Science ID: IHE-5534-2023 

Research

organic synthesis; β-amino acid synthesis; miniprotein design, synthesis and structure determination; peptide crystallisation

Education

2020 - present PhD studies in Chemical Sciences; Department of Bioorganic Chemistry, Wrocław University of  Science and Technology; Thesis; Design, synthesis and structure analysis of miniproteins containing β-amino acid building blocks; Supervisor: Prof. dr hab. inż. Łukasz Berlicki

2020 - MSc in Medicinal Chemistry; Department of Bioorganic Chemistry, Wroclaw University of Science and Technology; Thesis: Three component reaction of condensation of proline and its analogues with trialkyl orthoformate and dialkyl phosphite; Supervisor: Dr inż. Ewa Chmielewska

2019 - BSc in Chemistry; Department of Bioorganic Chemistry, Wroclaw University of Science and Technology; Thesis: Phosphonylation of heteroaromatic lithium reagents as a general route for synthesis of heteroaromatic phosphonates; Supervisor: Dr inż. Ewa Chmielewska

Grant participation

11.2022-present contractor: OPUS, National Science Centre; Grant ID: 2021/43/B/ST4/01837; Title: De novo design of cavity-incorporating mini-proteins and their application in catalysis; grant PI: prof. dr hab. inż. Łukasz Berlicki

04.2019-10.2019 contractor: HARMONIA, National Science Centre; Grant ID: 2017/26/M/ST5/00437; Title: Aminophosphonates containing fluorine atoms as inhibitors of aminopeptidases and their potential use in the study of enzyme-inhibitor interactions; grant PI: prof. dr hab. inż. Paweł Kafarski

Cooperation

2021-present Institute of Bioorganic Chemistry of the Polish Academy of Sciences, Department of Structure and Function of Biomolecules; Prof. dr hab. Wojciech Rypniewski, dr Magdalena Bejger

Awards

1. Best poster presentation, 1^st award for outstanding scientific research and excellent poster presentation entitled “From computational design to stable miniproteins”; 26^th Polish Peptide Symposium, 2023, Stare Jabłonki, Poland

Conference communications

1. N. Miodowska, Ł. Berlicki: From computational design to stable miniproteins; 26^th Polish Peptide Symposium, 2023, Stare Jabłonki, Poland, poster
2. N. Miodowska, A. Nielsen, Ł. Berlicki: De novo design and synthesis of miniproteins that contain non-native helices; ChemBiotIC Chemistry & Biotechnology International Conference, 2023, online event, poster
3. N. Miodowska, A. Szczepańska, Ł. Berlicki: Design and synthesis of miniproteins stabilised by hydrophobic and cation-π interactions; XIX Polish Seminar for PhD Students and Students „Na pograniczu Chemii i Biologii”, 2023, Trzebieszowice, Poland, oral presentation and member of the organising committee
4.  N. Miodowska, A. Szczepańska, Ł.  Berlicki: De novo design and synthesis of EHE miniproteins that contain unnatural β-amino acid building blocks; RSC Chemical Biology Symposium, 2023, London, England, poster
5. N. Miodowska, J. Basha Shaik, A. Szczepańska, Ł. Berlicki: De novo designed β-amino acid containing miniproteins of EEH topology; 64^th Scientific Congress of the Polish Chemical Society, 2022, Lublin, Poland, poster
6. N. Wojtowicz, E. Chmielewska: Phosphonylation of heteroaromatic lithium reagents as a general route for synthesis of heteroaromatic phopshonates; European Workshop on Phosphorus Chemistry - EWPC 14/2017, 2017, Cluj-Napoca, Romania, oral presentation

Workshops

1. 64th Polish Crystallography Conservatoire, 2023, Wrocław, Poland
2. Scientific Workshop of the Polish Crystallographic Association "Electron diffractometry" and Session of Young Crystallographers Section of the Polish Crystallographic Association, 2023, Wrocław, Poland
3. Annual NanoTemper Technologies Symposium & Workshop; 2022, Kraków, Poland.

Publications

1. Chmielewska, E.; Miodowska, N.; Dziuk, B.; Psurski, M.; Kafarski, P. One-Pot Phosphonylation of Heteroaromatic Lithium Reagents: The Scope and Limitations of Its Use for the Synthesis of Heteroaromatic Phosphonates. Molecules 2023, 28, 3135, https://doi.org/10.3390/mole­cules28073135