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Department of Bioorganic Chemistry

Rafał Latajka

latajka2.jpgBorn: January 24, 1972, Wrocław, Poland

Status: married, two sons

Hobby: cooking, history, sport – supporter of WKS Śląsk Wrocław

Address:

Department of Bioorganic Chemistry,

Faculty of Chemistry,

Wroclaw University of Science and Technology,

Wybrzeże Wyspianskiego 27,

50-370 Wroclaw, Poland

Tel: 0048 71 320 2463, Fax: 0048 71 320 2427

e-mail: rafal.latajka@pwr.edu.pl

ORCID: 0000-0003-2943-2838

Education

  • 2022 — Faculty of Chemistry, Wrocław University of Technology, full professor in Chemistry.
  • 2009 — Faculty of Chemistry, Wrocław University of Technology, habilitation in Chemistry.
  • 2001 — Faculty of Chemistry, Wrocław University of Technology, PhD in Chemistry, supervisor: Prof. Paweł Kafarski.
  • 1996 — Faculty of Chemistry, University of Wrocław, MSc in Chemistry, supervisor: Prof. Henryk Kozłowski.

Employment

  • 2022 – Full Professor, Department of Bioorganic Chemistry, Wrocław University of Science and Technology.
  • 2013 – Associate Professor, Department of Bioorganic Chemistry, Wrocław University of Technology.
  • 2001 – Assistant Professor, Department of Bioorganic Chemistry, Wrocław University of Technology.  
  • 1997 – PhD. student, Department of Bioorganic Chemistry, Wroclaw University of Technology.

Fellowships and scientific visits

  • Germany, University of Bielefeld, Department of Chemistry, Group of Prof. Norbert Sewald, DAAD Fellowship, 2009 (3 weeks);
  • Germany, University of Bielefeld, Department of Chemistry, Group of Prof. Norbert Sewald, DAAD Fellowship, 2008 (2 weeks);
  • Italy, University of Naples “Federico II”, Department of Chemistry, Department of Bioinorganic Chemistry, Postdoctoral Marie Curie Fellowship, 2003 (12 months);
  • Poland, Adam Mickiewicz University, Poznań, Department of Chemistry, Prof. Henryk Koroniak Group, Fellowship of Foundation of Polish Science, 2002 (3 months).

Research interests

Design of novel, low-molecular weight enzyme inhibitors. Synthesis and activity of antifreezing glycopeptides (AFGP), Application of NMR spectroscopy to structure-activity relationship studies, Design, structure and application of peptidomimetics and  peptidic foldamers.

International research co-operations

  • Prof. Norbert Sewald, University of Bielefeld, Germany.
  • Prof. Anna Maria Papini, University of Florence, Italy
  • Prof. Paolo Rovero, University of Florence, Italy
  • Prof. Francisco Garcia Canovas, University of Murcia, Spain
  • Prof. J. M. de los Santos, University of the Basque Country, Vitoria, Spain

Professional memberships and functions

  • Polish Chemical Society (since 1992)
  • European Peptide Society (since 2002)
  • Member of the main board of Polish Chemical Society (2016 – 2018, 2019 – 2021 and 2022 – 2024). I-st Vicepresident of the Society (2019 – 2021)
  • Head of PhD Studies of Faculty of chemistry (2020 – 2024)

Awards

  • 2001 - Award of Dean of Faculty of Chemistry, Wroclaw University of Technology.
  • 2010 - Award of Rector of Wroclaw University of Technology
  • 2015 - Award of Rector of Wroclaw University of Technology
  • 2019 – Medal of Polish Chemical Society
  • 2022 – Award of Dean of Faculty of Chemistry, Wroclaw University of Science and Technology
  • 2023 – Award of Rector of Wroclaw University of Science and Technology

Selected publications

  1. P Ledwon, W. Goldeman, K. Haldys, M. Jewginski, G. Calamai, J. Rossowska, A.M. Papini, P. Rovero, R. Latajka, Tripeptides conjugated with thiosemicarbazones: new inhibitors of tyrosinase for cosmeceutical use, J. Enzyme Inhibit.&Med. Chem., 2023, 38, 1
  2. F. Nuti, M. Larregola, A. Staskiewicz, B. Retzl, N. Tomasevic, L. Macchia, M.E. Street, M. Jewginski, O. Lequin, R. Latajka, P.  Rovero, C.W.  Gruber, M. Chorev, A.M. Papini, Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4-and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues, J. Enzyme Inhibit.&Med. Chem., 2023, 38, 1
  3. A. Staskiewicz, M. Quagliata, F. Real-Fernandez, F. Nuti, R. Lanzillo, V. Brescia-Morra, H. Rusche, M. Jewginski, A. Carotenuto, R. Aharoni, R. Arnon, P. Rovero, R.  Latajka, Role of Helical Structure in MBP Immunodominant Peptides for Efficient IgM Antibody Recognition in Multiple Sclerosis, Frontiers in Chemistry, 2022, 10, 885180
  4. M.P. Jewginski, M. Makowski, M.  Pawelczak, W. Goldeman, A. Trojanowska-Laskowska, P. Kafarski, R. Latajka, Synthesis of Hybrid Tripeptide Peptidomimetics Containing Dehydroamino Acid and Aminophosphonic Acid in the Chain and Evaluation of Their Activity toward Cathepsin C, Chem.&Biodiv. 2022, 19, 5
  5. H. Gruss, R.C. Feiner, R.Mseya, D.C. Schröder, M. Jewginski, K.M. Müller, R. Latajka, A. Marion, N. Sewald, Peptide stapling by late-stage Suzuki-Miyaura cross-coupling, Beilstein J. Org. Chem. 2022, 18, 1
  6. D. Tarasek, B. Gasowska-Bajger, B. Frackowiak-Wojtasek, C. Kersten, M. Jewginski, L. Kolodziej, R. Latajka, H. Wojtasek, Oxidation of dobutamine and dopamine by horseradish peroxidase, J. Mol. Struct. 2022, 1252
  7. P. Ledwon, A.M. Papini, P.  Rovero, R. Latajka, Peptides and Peptidomimetics as Inhibitors of Enzymes Involved in Fibrillar Collagen Degradation, Materials 2021, 14, 12
  8. M. Jewginski, K. Haremza, J. M. de los Santos, Z. Es Sbai, B. Oszywa, M. Pawełczak, F. Palacios, R. Latajka Phosphinotripeptidic inhibitors of leucylaminopeptidases. Int. J. Mol. Sci. 2021, 22, 5090 
  9. A. Staśkiewicz, P. Ledwoń, P. Rovero, A.M. Papini, R. Latajka Triazole-modified peptidomimetics: an opportunity for drug discovery and development Frontiers in Chemistry 2021, 9, article 674705  
  10. Hałdys, K.; Goldeman, W.; Anger-Góra, N.; Rossowska, J.; Latajka, R., Monosubstituted acetophenone thiosemicarbazones as potent inhibitors of tyrosinase: synthesis, inhibitory studies and molecular docking. Pharmaceuticals 2021, 14, 74 
  11. Ledwon, P.; Errante, F.; Papini, A. M.; Rovero, P.; Latajka, R., Peptides as active ingredients: A challenge for cosmeceutical industry. Chem. Biodiversity 2021, 18, 2 
  12. Hałdys K., Goldeman W., Jewgiński M., Wolińska E., Anger-Góra N., Rossowska J., Latajka R., Halogenated aromatic thiosemicarbazones as potent inhibitors of tyrosinase and melanogenesis Bioorganic Chemistry 2020, 94, 103419
  13. Errante F.; Ledwoń P.; Latajka R.; Rovero P.; Papini A.M., Cosmeceutical peptides in the framework of sustainable wellness economy Frontiers in Chemistry 2020, 8, 572923   
  14. Hałdys K., Latajka R., Thiosemicarbazones with tyrosinase inhibitory activity MedChemComm 2019, 10, 378 
  15. Schröder D.C., Kracker O., Fröhr T., Góra J., Jewginski M., Nieß A., Antes I., Latajka R., Marion A., Sewald N., 1,4-Disubstituted 1H-1,2,3-triazole containing peptidotriazolamers: A new class of peptidomimetics with interesting foldamer properties. Frontiers in Chemistry 2019, 7, 1 
  16. Wolinska, E.; Hałdys, K.; Góra, J.; Olszewski, T.K.; Boduszek, B.; Latajka, R., Phosphonic and phosphinic acid derivatives as novel tyrosinase inhibitors: Kinetic studies and molecular docking. Chem. Biodiversity 2019, 16, art. e1900167 
  17. Urbańczyk M., Jewgiński M, Krzciuk-Gula J., Góra J., Latajka R., Sewald N., Synthesis and conformational preferences of short analogues of antifreeze glycopeptides (AFGP), Beilstein J. Org. Chem. 2019, 15, 1581 
  18. Hałdys, K.; Goldeman, W.; Jewgiński, M.; Wolińska, E.; Anger, N.; Rossowska, J.; Latajka, R.; Inhibitory properties of aromatic thiosemicarbazones on mushroom tyrosinase: Synthesis, kinetic studies, molecular docking and effectiveness in melanogenesis inhibition, Bioorg. Chem, 2018, 81, 577 
  19. Malik-Gajewska, M.; Trynda, J.; Zierkiewicz, W.; Helios, K.; Latajka, R.; Wietrzyk, J.; Michalska, D.; Picoplatin-based complexes with the bioactive orotate and 5-fluoroorotate ligands: Synthesis, DFT calculations, structure, spectroscopic characterization and in vitro cytotoxicity, J. Mol. Struct. 2018, 1171, 155 
  20. Kracker, O.; Góra, J.; Krzciuk-Gula, J.; Marion, A.; Neumann, B.; Stammler, H-G.; Niess, A.; Antes, I.; Latajka, R.; Sewald, N.; 1,5-Disubstituted 1,2,3-Triazole-Containing Peptidotriazolamers: Design Principles for a Class of Versatile Peptidomimetics , Chem. Eur. J., 2018, 24, 953 
  21. Marion, A.; Gora, J.; Kracker, O.; Frohr, T.; Latajka, R.; Sewald, N.; Antes, I.; Amber-Compatible Parametrization Procedure for Peptide-like Compounds: Application to 1,4- and 1,5-Substituted Triazole-Based Peptidomimetics, J. Chem. Inf. Model., 2018, 58, 90 
  22. Urbańczyk, M.; Góra, J.; Latajka, R.; Sewald, N.; Antifreeze glycopeptides: from structure and activity studies to current approaches in chemical synthesis. Amino Acids 2017, 49, 2, 209 
  23. Lenartowicz, P.; Makowski, M.; Oszywa, B.; Haremza, K.; Latajka, R.; Pawełczak, M.; Kafarski, P., Addition of thiols to the double bond of dipeptide C-terminal dehydroalanine as a source of new inhibitors of cathepsin C. Biochimie 2017. 139, 46 
  24. Lamch, Ł.; Tylus, W.; Jewgiński, M.; Latajka, R.; Wilk, K.A.; Location of Varying Hydrophobicity Zinc(II) Phthalocyanine-Type Photosensitizers in Methoxy Poly(ethylene oxide) and Poly(L‑lactide) Block Copolymer Micelles Using 1H NMR and XPS Techniques, J. Phys. Chem. B., 2016, 120, 49, 12768 
  25. Góra, J.; Latajka, R.; Involvement of Cysteine Proteases in Cancer, Curr. Med. Chem., 2015, 22, 944 
  26. Dudka, I.; Kossowska, B.; Senhadri, H.; Latajka, R.; Hajek, J.; Andrzejak, R.; Antonowicz-Juchniewicz, J.; Gancarz, R.Metabonomic analysis of serum of workers occupationally exposed to arsenic, cadmium and lead for biomarker research: A preliminary study Environment International, 2014, 68, 71 
  27. Poreba, M.; Mihelic, M.; Krai, P.; Rajkovic, J.; Krezel, A.; Pawelczak, M.; Klemba, M.; Turk, D.; Turk, B.; Latajka, R.; Drag, M., Unnatural amino acids increase activity and specificity of synthetic substrates for human and malarial cathepsin C, Amino Acids, 2014, 56, 931 
  28. Jewginski, M.; Krzciuk-Gula, J.; Makowski, M.; Latajka, R.; Kafarski, P., Conformation of dehydropentapeptides containing four achiral amino acid residues - controlling the role of L-valine Beilsten J. Org.Chem., 2014, 10, 660 
  29. Buczek, A.; Makowski, M.; Jewginski, M.; Latajka, R.; Kupka, T.; Broda, M.A. Toward Engineering Efficient Peptidomimetics. Screening Conformational Landscape of Two Modified Dehydroaminoacids Biopolymers, 2014, 101, 1, 28 
  30. Jewginski, M.; Latajka, R.; Krezel, A.; Haremza, K.; Makowski, M.; Kafarski, P. Influence of solvents on conformation of dehydropeptides J. Mol. Struct., 2013, 1035, 129 
  31. Pluskota-Karwatka, D.; Pawlowicz, A.J.; Bruszynska, M.; Greszkiweicz, A.; Latajka, R.; Kronberg, L., Identification of Adducts Formed in the Reactions of Malonaldehyde-glyoxal and Malonaldehyde-methylglyoxal with Adenosine and Calf Thymus DNA Chemistry &Biodiversity, 2010, 7, 4, 959 
  32. Lisowski, M.; Jaremko, L.; Jaremko, M.; Mazur, A.; Latajka, R., Makowski, M. , Effect of the Delta Phe Residue Configuration on a Didehydropeptides Conformation: A Combined CD and NMR Study Biopolymers, 2010, 93, 12, 1055 
  33. Latajka, R.; Jewginski, M.; Makowski, M., Krężel, Conformational studies of hexapeptides containing two dehydroamino acid residues in positions 3 and 5 in peptide chain. J. Mol. Struci. 2008, 892, 446 
  34. Latajka, R.; Jewginski, M.; Makowski, M.; Pawełczak, M.; Huber, T.; Sewald, N.; Kafarski, P., Pentapeptides containing two dehydrophenylalanine residues - synthesis, structural studies and evaluation of their activity towards cathepsin C. J. Petide. Sci. 2008, 14, 1084. 
  35. Latajka, R.; Jewginski, M.; Makowski, M.; Krężel, A., Paluch, S.Conformational studies of hexapeptides containing two dehydroamino acid residues in positions 2 and 5 in peptide chain. Biopolymers, 2008, 89, 691 
  36. Lisowski, M.; Latajka, R.; Picur, B.; Lis, T.; Bryndal, I.; Rospenk, M.; Makowski, M.; Kafarski, P., Combined effect of the ΔPhe or ΔAla residue and the p-nitroanilide group on the didehydropeptides conformation, Biopolymers, 2008, 89, 220. 
  37. Żymańczyk-Duda, E.; Brzezińska-Rodak, M.; Klimek-Ochab, M.; Latajka, R.; Kafarski, P.; Lejczak, B., Chiral O-phosphorylated derivative of 2-hydroxy-2-phenylethylphosphonate as a valuable product of microbial biotransformation of diethyl 2-oxo-2-phenylethylphosphonate, J. Mol. Catal. B: Enzym, 2008, 52-53, 74 
  38. Latajka, R.; Krężel, A.; Mucha, A.; Jewginski, M.; Kafarski, P., Conformational investigations of bis(α-aminoalkyl)phosphonic acids and studies of stability of their complexes with Cu(II), J. Mol. Struct. 2008, 877, 64 
  39. Młynarz, P.; Jewginski, M.; Śliwińska, S.; Latajka, R.; Schroeder, G.; Kafarski, P. „Twin” phosphorus atoms of tetraehtyl 2-methylpiperyd-1-ylmethylenebisphosphonate. Heteroatom Chem. 2007, 18, 774 
  40. Latajka, R.; Makowski, M.; Jewginski, M.; Pawełczak, M.; Koroniak, H.; Kafarski, P. Peptide p-nitrophenylanilides containing (E)-dehydrophenylalanine - synthesis, structural studies and evaluation of their activity towards cathepsin C. New J. Chem. 2006, 30, 1009. 
  41. Frąckowiak, B.; Olejniczak, T.; Latajka, R.; Białońska, A.; Ciunik, Z.; Lochyński, S. Stereochemistry of terpene derivatives. Part 4: Fragrant terpenoid derivatives with an unsaturated gem-dimethylbicyclo[3.1.0]hexane system. Tetrahedron: Asymmetry 2005, 16, 3352. 
  42. Zon, J.; Szefczyk, B.; Sawka-Dobrowolska, W.; Gancarz, R.; Kucharska-Zon, M.; Latajka, R.; Amrhein, N.; Miziak, P.; Szczepanik, W., Experimental and ab initio calculated structures of 2-aminoindane-2-phosphonic acid, a potent inhibitor of phenylalanine ammonia-lyase, and theoretical studies of its binding to the model enzyme structure. New J. Chem. 2004, 28, 1048. 
  43. Gumienna-Kontecka, E.; Galezowska, J.; Drąg, M.; Latajka, R.; Kafarski, P.; Kozłowski, H. Coordination abilities of substituted beta-aminophosphonates towards Cu2+ and Zn2+ ions. Inorganica Chimica Acta 2004, 357, 1632. 
  44. atajka, R.; Jewginski, M.; Pawełczak, M.; Makowski, M.; Kafarski, P., Conformational preferences and biological activity of short peptides containing (E)-dehydrophenylalanine. Biopolymers 2003, 73, 301.
  45. Drąg, M.; Latajka, R.; Gumienna-Kontecka, E.; Kozłowski, H.; Kafarski, P. Stereoselective synthesis, solution structure and metal complexes of (1S,2S)-2-amino-1-hydroxyalkylphosphonic acids. Tetrahedron-Asymmetry 2003, 14, 1837. 
  46. Krężel, A.; Latajka, R.; Bujacz, G.D.; Bal, W., Coordination properties of tris(2-carboxyethyl)phosphine, a newly introduced thiol reductant, and its oxide. Inorg. Chem. 2003, 42, 1994. 
  47. Kilyen, M.; Lakatos, A.; Latajka, R.; Labadi, I.; Salifoglou, A.; Raptopoulou, C.P.; Kozłowski, H.; Kiss, T., Al(III)-binding properties of iminodiacetic acid, nitrilotriacetic acid and their mixed carboxylic-phosphonic derivatives. J. Chem. Soc. Dalton Trans. 2002, 3578. 
  48. Drąg, M.; Latajka, R.; Gancarz, R.; Kafarski, P.; Pirat, J.L.; Cristau, H.J., Regio- and stereoselective synthesis, solution conformations of 2-amino-1-hydroxy-2-arylethylphosphonic esters and acids. Phosphrus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 2191. 
  49. Latajka, R.; Gancarz, R.; Kafarski, P., Slow inversion of stereoisomers of 4-amino-1-benzylpiperid-4-yl phosphonic acids and their esters. Phosphorus, Sulfur, and Silicon, and Rel. Elem. 2002, 177, 1575. 
  50. Latajka, R.; Drąg, M.; Gancarz, R.; Kafarski, P., Solution conformations of 2-amino-1-hydroxy-2-aryl ethylphosphonic acids and their diethyl esters. J. Mol. Struct. 2002, 605, 79. 
  51. Makowski, M.; Pawełczak, M.; Latajka, R.; Nowak, K.; Kafarski, P., Synthesis of tetrapeptide p-nitrophenylanilides containing dehydroalanine and dehydrophenylalanine and their influence on cathepsin C activity. J. Pept. Sci. 2001, 7, 141. 
  52. Boduszek, B.; Latajka, R.; Walkowiak, U., Acid-catalyzed cleavage of some chromone, coumarin and pyrone derivatives of aminomethylphosphonic acid. Products and kinetics of the reaction. Pol. J. Chem. 2001, 75, 63. 
  53. Gancarz, R.; Latajka, R.; Halama, A.; Kafarski, P., Slow inversion of stereoisomers of cyclic GABA analogues. Magn. Res. Chem. 2000, 38, 867. 
  54. Gancarz, R.; Latajka, R.; Maluszek, B.; Żymańczyk-Duda, E.; Kafarski, P., Hydrogen bonding in diethyl 2-hydroxypropylphosphonate - an example of equilibrium between intramolecular and intermolecular bonding. Magn. Res. Chem. 2000, 38, 197. 
  55. Bal, W.; Dyba, M.; Kasprzykowski, F.; Kozłowski, H.; Latajka, R.; Lankiewicz, L.; Mackiewicz, Z.; Pettit, L.D., How non-bonding amino acid side-chains may enormously increase the stability of a Cu(II)-peptide complex. Inorg. Chim. Acta 1998, 283, 1.

 

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