Born: July 31st, 1994, Wrocław, Poland
Room: 311, building A2
Phone: +48 71 320 35 12
e-mail: wojciech.tabor@pwr.edu.pl
Hobby: History, reading books, playing the keyboard
ORCID: 0000-0002-3682-2765

Research

Biological evaluation of potential urease inhibitors against both purified enzyme and whole cells of microorganisms, including known pathogens for which urease acts as a virulence factor (e.g. Cryptococcus neoformans, Proteus mirabilis, Helicobacter pylori). Among the studied compounds are catechol-based phosphonates and phosphinates, 1,2-benzisoselenazol-3(2H)-one derivatives, flavonoids and thiourea derivatives. In addition to urease inhibition measurement, the influence of the compounds on the viability of pathogens is evaluated as well.

Education

2018 – 2023– PhD in Biotechnology, Department of Bioorganic Chemistry,
Wrocław University of Science and Technology, Supervisor: prof. dr hab. inż. Artur Mucha

2017 – 2018 – MSc degree in Biotechnology, Specialization: Environmental Biotechnology,
Wrocław University of Science and Technology, Topic of the thesis: “Gravimetric method of
biofilm measurement”, Supervisor: dr Agnieszka Grabowiecka

Prizes

2021 - Laureate of second edition of Primus (“Działanie 1”)

Cooperation

• Department of Microbiology, Wrocław Medical University, Poland (prof. Grażyna Gościniak’s group)
• Department of Pharmaceutical Microbiology and Parasitology, Wrocław Medical University, Poland
  (dr hab. Urszula Nawrot’s group)
• Laboratory of Organic Chemistry, Faculty of Chemistry, National and Kapodistrian University of
  Athens (prof. Stamatia Vassiliou’s group)
• Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toruń
  (prof. Jacek Ścianowski’s group)
• Department of Food Chemistry and Biocatalysis, Faculty of Biotechnology and Food Science, Wrocław
  University of Environmental and Life Sciences (prof. Mirosław Anioł’s group)

Conference communications

1. Tabor W, Ntatsopoulos V, Vassiliou S, Mucha A, Berlicki Ł, Grabowiecka A, “Novel cysteine-targeting inhibitors of bacterial urease”, EFMC-ACSMEDI Medicinal Chemistry Frontiers, 10 - 13 June 2019, Kraków, Poland (Poster)
2. Tabor W, Pagoni A, Grabowiecka A, Mucha A, Vassiliou S, Berlicki Ł, “Covalent inhibition of bacterial urease by bifunctional catechol-based phosphonates and phosphinates”, EFMC-ISMC & EFMC-YMSC Virtual Poster Session, 09 September 2020, Online – (Poster)
3. Tabor W, Krzyżek P, Nawrot U, Mucha A, Berlicki Ł, Grabowiecka A, „Ebselen based inhibitors of urease affect the viability of Cryptococcus neoformans and Helicobacter pylori”, ACCORD Interdisciplinary Conference on Drug Sciences, 26 – 28 May 2022, Warszawa, Poland (Poster + Spotlight presentation)
4. Tabor W, Macegoniuk K, Grabowiecka A, Ciurli S, Mazzei L, Mucha A, “Ebselen derivatives as picomolar inhibitors of bacterial ureases”, ESCMID/ASM Conference on Drug Development to Meet the Challenge of Antimicrobial Resistance, 4 – 7 October 2022, Dublin, Ireland (Poster)
5. Tabor W, Maślanka M, Grabowiecka A, Nawrot U, Krzyżek P, Mucha A, Berlicki Ł, “Ebselen-based compounds act as covalent inhibitors of microbial ureases in nanomolar concentrations”, Tetrahedron Symposium, 27-30 June 2023, Goteborg, Sweden (Poster)
   

Publications

1. Macegoniuk K, Tabor W, Mazzei L, Cianci M, Giurg M, Olech K, Burda-Grabowska M, Kaleta R, Grabowiecka A, Mucha A, Ciurli S, Berlicki Ł. Optimized Ebselen-Based Inhibitors of Bacterial Ureases with Nontypical Mode of Action. J Med Chem. 2023, 66(3):2054-2063. doi: 10.1021/acs.jmedchem.2c01799
2. Maślanka M, Tabor W, Krzyżek P, Grabowiecka A, Berlicki Ł, Mucha A. Inhibitory activity of catecholic phosphonic and phosphinic acids against Helicobacter pylori ureolysis. Eur J Med Chem. 2023, 257:115528. doi: 10.1016/j.ejmech.2023.115528
3. Tabor W, Katsogiannou A, Karta D, Andrianopoulou E, Berlicki Ł, Vassiliou S, Grabowiecka A. Exploration of Thiourea-Based Scaffolds for the Construction of Bacterial Ureases Inhibitors. ACS Omega. 2023, 8(31):28783-28796. doi: 10.1021/acsomega.3c03702
4. Vassiliou S, Pagoni A, Węglarz-Tomczak E, Talma M, Tabor W, Grabowiecka A, Berlicki Ł, Mucha A. Phosphinic acid-based enzyme inhibitors. Phosphorus Sulfur Silicon Relat Elem. 2022, 197(5-6):451-456. doi: 10.1080/10426507.2021.2011882
5. Pagoni A, Grabowiecka A, Tabor W, Mucha A, Vassiliou S, Berlicki Ł. Covalent Inhibition of Bacterial Urease by Bifunctional Catechol-Based Phosphonates and Phosphinates. J Med Chem. 2021, 64(1):404-416. doi: 10.1021/acs.jmedchem.0c01143