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Department of Bioorganic Chemistry

Publications - Rafał Kowalczyk

2023

Mała, Ż. A.; Janicki, M. J.; Góra, R. W.; Konieczny, K. A.; Kowalczyk, R. Mechanochemical Assisted Chemoselective and Stereoselective Hydrogen-Bonding Catalyzed Addition of Dithiomalonates to Enones. Advanced Synthesis and Catalysis 2023, 365 (19), 3342–3352. View at Publisher.

2022

Kowalczyk, R. Mechanochemistry and High-Pressure Techniques in Asymmetric Organocatalysis. In Asymmetric Organocatalysis: New Strategies, Catalysts, and Opportunities: Volume 1-2; 2022; Vol. 1–2, pp 393–432. View at Publisher.

2021

Kucharski, D. J.; Kowalczyk, R.; Boratyński, P. J. Chiral Vicinal Diamines Derived from Mefloquine. Journal of Organic Chemistry 2021, 86 (15), 10654–10664. View at Publisher.

Mała, Ż. A.; Janicki, M. J.; Niedźwiecka, N. H.; Góra, R. W.; Konieczny, K. A.; Kowalczyk, R. Stereoselectivity Enhancement During the Generation of Three Contiguous Stereocenters in Tetrahydrothiophenes. ChemCatChem 2021, 13 (2), 574–580. View at Publisher.

Zielińska-Błajet, M.; Mała, Ż. A.; Kowalczyk, R. Efficacy of Selenourea Organocatalysts in Asymmetric Michael Reactions under Standard and Solvent-Free Conditions. Molecules 2021, 26 (23). View at Publisher.

2020

Dajek, M.; Pruszczyńska, A.; Konieczny, K. A.; Kowalczyk, R. Cinchona Squaramide-Catalyzed Intermolecular Desymmetrization of 1,3-Diketones Leading to Chiral 1,4-Dihydropyridines. Advanced Synthesis and Catalysis 2020, 362 (17), 3613–3620. View at Publisher.

2019

Ignatiuk, Ż. A.; Janicki, M. J.; Góra, R. W.; Konieczny, K.; Kowalczyk, R. Applications of Thermal Activation, Ball-Milling and Aqueous Medium in Stereoselective Michael Addition of Nitromethane to Enynones Catalyzed by Chiral Squaramides. Advanced Synthesis and Catalysis 2019, 361 (5), 1108–1116. View at Publisher.

2018

Dajek, M.; Kowalczyk, R.; Boratyński, P. J. Trans -1,2-Diaminocyclohexane-Based Sulfonamides as Effective Hydrogen-Bonding Organocatalysts for Asymmetric Michael-Hemiacetalization Reaction. Catalysis Science and Technology 2018, 8 (17), 4358–4363. View at Publisher.

Boratyński, P. J.; Gałęzowska, J.; Turkowiak, K.; Anisiewicz, A.; Kowalczyk, R.; Wietrzyk, J. Triazole Biheterocycles from Cinchona Alkaloids: Coordination and Antiproliferative Properties. ChemistrySelect 2018, 3 (32), 9368–9373. View at Publisher.

2017

Przydacz, A.; Kowalczyk, R.; Albrecht, Ł. Brønsted-Base-Catalyzed Remote Cascade Reactivity of 2,4-Dienones-Asymmetric Synthesis of Tetrahydrothiophenes. Organic and Biomolecular Chemistry 2017, 15 (45), 9566–9569. View at Publisher.

Gałęzowska, J.; Boratyński, P. J.; Kowalczyk, R.; Lipke, K.; Czapor-Irzabek, H. Copper(II) Complexes of Chiral 1,2,3-Triazole Biheterocyclic ‘Click’ Ligands Equipped in Cinchona Alkaloid Moiety. Polyhedron 2017, 121, 1–8. View at Publisher.

Macegoniuk, K.; Kowalczyk, R.; Rudzińska, A.; Psurski, M.; Wietrzyk, J.; Berlicki, Ł. Potent Covalent Inhibitors of Bacterial Urease Identified by Activity-Reactivity Profiling. Bioorganic and Medicinal Chemistry Letters 2017, 27 (6), 1346–1350. View at Publisher.

2016

Kowalczyk, R.; Boratyński, P. J. Stereoselective Thia-Michael 1,4-Addition to Acyclic 2,4-Dienones and 2-En-4-Ynones. Advanced Synthesis and Catalysis 2016, 358 (8), 1289–1295. View at Publisher.

Boratyński, P. J.; Kowalczyk, R. Click-Dimerized Cinchona Alkaloids. Journal of Organic Chemistry 2016, 81 (17), 8029–8034. View at Publisher.

Boratyński, P. J.; Kowalczyk, R.; Kobylańska, A.; Bąkowicz, J. Tricyclic Quaternary Ammonium Salts Derived from Cinchona Alkaloids. Journal of Organic Chemistry 2016, 81 (24), 12489–12493. View at Publisher.

2015

Kowalczyk, R.; Boratyński, P. J.; Wierzba, A. J.; Bąkowicz, J. Site and Stereoselectivity in Sulfa-Michael Addition to Equivocally Activated Conjugated Dienes. RSC Advances 2015, 5 (82), 66681–66686. View at Publisher.

2014

Bizet, V.; Kowalczyk, R.; Bolm, C. Fluorinated Sulfoximines: Syntheses, Properties and Applications. Chemical Society Reviews 2014, 43 (8), 2426–2438. View at Publisher.

Kowalczyk, R.; Wierzba, A. J.; Boratyński, P. J.; Bąkowicz, J. Enantioselective Conjugate Addition of Aliphatic Thiols to Divergently Activated Electron Poor Alkenes and Dienes. Tetrahedron 2014, 70 (35), 5834–5842. View at Publisher.

2013

Kowalczyk, R.; Nowak, A. E.; Skarzewski, J. Organocatalytic Asymmetric Addition of Aliphatic Thiols to Nitro Olefins and Nitrodienes. Tetrahedron Asymmetry 2013, 24 (8), 505–514. https://doi.org/10.1016/j.tetasy.2013.03.007.

2011

Miyasaka, M.; Hirano, K.; Satoh, T.; Kowalczyk, R.; Bolm, C.; Miura, M. Copper-Catalyzed Direct Sulfoximination of Azoles and Polyfluoroarenes under Ambient Conditions. Organic Letters 2011, 13 (3), 359–361. https://doi.org/10.1021/ol102844q.

Kowalczyk, R.; Edmunds, A. J. F.; Hall, R. G.; Bolm, C. Synthesis of CF3-Substituted Sulfoximines from Sulfonimidoyl Fluorides. Organic Letters 2011, 13 (4), 768–771. https://doi.org/10.1021/ol103030w.

2010

Chaladaj, W.; Kowalczyk, R.; Jurczak, J. Enantioselective Construction of Cis-2,6-Disubstituted Dihydropyrans: Total Synthesis of (-)-Centrolobine. Journal of Organic Chemistry 2010, 75 (5), 1740–1743. https://doi.org/10.1021/jo902167r.

2009

Kowalczyk, R.; Skarzewski, J. Asymmetric Nitroaldol Reaction Catalyzed by Copper-Diamine Complexes: Selective Construction of Two Contiguous Stereogenic Centers. Tetrahedron Asymmetry 2009, 20 (21), 2467–2473. https://doi.org/10.1016/j.tetasy.2009.10.001.

Kowalczyk, R.; Kwiatkowski, P.; Skarzewski, J.; Jurczak, J. Enantioselective Nitroaldol Reaction Catalyzed by Sterically Modified Salen-Chromium Complexes. Journal of Organic Chemistry 2009, 74 (2), 753–756. https://doi.org/10.1021/jo802107b.

2008

Kowalczyk, R.; Sidorowicz, Ł.; Skarzewski, J. Asymmetric Henry Reaction Catalyzed by Chiral Secondary Diamine-Copper(II) Complexes. Tetrahedron Asymmetry 2008, 19 (19), 2310–2315. https://doi.org/10.1016/j.tetasy.2008.09.032.

2007

Kowalczyk, R.; Skarzewski, J. Selective Nucleophilic Substitution Using Pyrazolate Anions: Easy Approach to Modular Chiral Ligands with Complexing Pyrazole Moieties. Polish Journal of Chemistry 2007, 81 (11), 1987–1999.

Kowalczyk, R.; Sidorowicz, Ł.; Skarzewski, J. Asymmetric Nitroaldol Reaction Catalyzed by a Chromium(III)-Salen System. Tetrahedron Asymmetry 2007, 18 (21), 2581–2586. https://doi.org/10.1016/j.tetasy.2007.10.023.

2006

Kowalczyk, R.; Skarzewski, J. O-Methylatrolactic Acid as a New Reagent for Determination of the Enantiomeric Purity and Absolute Configuration of Chiral Alcohols and Amines. Tetrahedron Asymmetry 2006, 17 (9), 1370–1379. View at Publisher.

2005

Kowalczyk, R.; Skarzewski, J. Regioselective Synthesis of Optically Active (Pyrazolyl)Pyridines with Adjacent Quaternary Carbon Stereocenter: Chiral N,N-Donating Ligands. Tetrahedron 2005, 61 (3), 623–628. View at Publisher.

Zielinska-Błajet, M.; Kowalczyk, R.; Skarzewski, J. Ring-Closure Reactions through Intramolecular Substitution of Thiophenoxide by Oxygen and Nitrogen Nucleophiles: Simple Stereospecific Synthesis of 4,5-Dihydroisoxazoles and 4,5-Dihydropyrazoles. Tetrahedron 2005, 61 (22), 5235–5240. View at Publisher.

2004

Laureyn, I.; Stevens, C. V.; Kowalczyk, R. Entry to γ-Amino-α-Bromo-Alkenylphosphonates by a Bromination-Elimination Sequence. Synlett 2004, No. 10, 1823–1825. View at Publisher.

2002

Kowalczyk, R.; Skarzewski, J. New Version of the TEMPO-Based Catalytic System for the Oxidation of Alcohols to Aldehydes. Polish Journal of Chemistry 2002, 76 (10), 1413–1417.

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