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Department of Bioorganic Chemistry

Rafał Kowalczyk

kowalczyk2.jpg

Born: April 3rd, 1978, Oława, Poland

Room: 312, building A2

Phone: +48 71 320 4039

e-mail: rafal.kowalczyk@pwr.edu.pl

Hobby: sci-fi movies

ORCID0000-0001-5228-9131

Scopus ID35290490800

Web of Science ID: R-6820-2019

Google Scholar: JVO46DgAAAAJ

Education

2018 – Habilitation in Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Poland

2006 – PhD in Chemistry, supervisor: prof. Jacek Skarżewski, Faculty of Chemistry, Wrocław University of Technology, Poland

2002 – MSc in Chemistry, Faculty of Chemistry, Wrocław University of Technology, Wrocław, Poland

Fellowships

2009-2010, Institute of Organic Chemistry, RWTH Aachen University, prof. Carsten Bolm;

2002, Ghent University, prof. Christian V. Stevens.

Research

  • Asymmetric catalysis;
  • C-H functionalization of Csp2-H and Csp3-H bonds

Cooperation

  • prof. Łukasz Albrecht (Lodz University of Technology)
  • prof. Debabrata Maiti (IIT Mumbai)
  • prof. Geraldine Masson (Institut de Chimie des Substances Naturelles (ICSN), Gif-sur-Yvette)

Selected publications (All publications)

  1. Mała, Ż. A.; Janicki, M. J.; Góra, R. W.; Konieczny, K. A.; Kowalczyk, R. Mechanochemical Assisted Chemoselective and Stereoselective Hydrogen-Bonding Catalyzed Addition of Dithiomalonates to Enones. Advanced Synthesis and Catalysis 2023, 365 (19), 3342–3352. View at Publisher.
  2. Kowalczyk, R. Mechanochemistry and High-Pressure Techniques in Asymmetric Organocatalysis. In Asymmetric Organocatalysis: New Strategies, Catalysts, and Opportunities: Volume 1-2; 2022; Vol. 1–2, pp 393–432. View at Publisher.
  3. Kucharski, D. J.; Kowalczyk, R.; Boratyński, P. J. Chiral Vicinal Diamines Derived from Mefloquine. Journal of Organic Chemistry 2021, 86 (15), 10654–10664. View at Publisher.
  4. Mała, Ż. A.; Janicki, M. J.; Niedźwiecka, N. H.; Góra, R. W.; Konieczny, K. A.; Kowalczyk, R. Stereoselectivity Enhancement During the Generation of Three Contiguous Stereocenters in Tetrahydrothiophenes. ChemCatChem 2021, 13 (2), 574–580. View at Publisher.
  5. Dajek, M.; Pruszczyńska, A.; Konieczny, K. A.; Kowalczyk, R. Cinchona Squaramide-Catalyzed Intermolecular Desymmetrization of 1,3-Diketones Leading to Chiral 1,4-Dihydropyridines. Advanced Synthesis and Catalysis 2020, 362 (17), 3613–3620. View at Publisher.
  6. Ignatiuk, Ż. A.; Janicki, M. J.; Góra, R. W.; Konieczny, K.; Kowalczyk, R. Applications of Thermal Activation, Ball-Milling and Aqueous Medium in Stereoselective Michael Addition of Nitromethane to Enynones Catalyzed by Chiral Squaramides. Advanced Synthesis and Catalysis 2019, 361 (5), 1108–1116. View at Publisher.
  7. Dajek, M.; Kowalczyk, R.; Boratyński, P. J. Trans -1,2-Diaminocyclohexane-Based Sulfonamides as Effective Hydrogen-Bonding Organocatalysts for Asymmetric Michael-Hemiacetalization Reaction. Catalysis Science and Technology 2018, 8 (17), 4358–4363. View at Publisher.
  8. Przydacz, A.; Kowalczyk, R.; Albrecht, Ł. Brønsted-Base-Catalyzed Remote Cascade Reactivity of 2,4-Dienones-Asymmetric Synthesis of Tetrahydrothiophenes. Organic and Biomolecular Chemistry 2017, 15 (45), 9566–9569. View at Publisher.
  9. Kowalczyk, R.; Boratyński, P. J. Stereoselective Thia-Michael 1,4-Addition to Acyclic 2,4-Dienones and 2-En-4-Ynones. Advanced Synthesis and Catalysis 2016, 358 (8), 1289–1295. View at Publisher.
  10. Boratyński, P. J.; Kowalczyk, R. Click-Dimerized Cinchona Alkaloids. Journal of Organic Chemistry 2016, 81 (17), 8029–8034. View at Publisher.
  11. Kowalczyk, R.; Boratyński, P. J.; Wierzba, A. J.; Bąkowicz, J. Site and Stereoselectivity in Sulfa-Michael Addition to Equivocally Activated Conjugated Dienes. RSC Advances 2015, 5 (82), 66681–66686. View at Publisher.
  12. Bizet, V.; Kowalczyk, R.; Bolm, C. Fluorinated Sulfoximines: Syntheses, Properties and Applications. Chemical Society Reviews 2014, 43 (8), 2426–2438. View at Publisher.
  13. Miyasaka, M.; Hirano, K.; Satoh, T.; Kowalczyk, R.; Bolm, C.; Miura, M. Copper-Catalyzed Direct Sulfoximination of Azoles and Polyfluoroarenes under Ambient Conditions. Organic Letters 2011, 13 (3), 359–361. View at Publisher.
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